منابع مشابه
Studies on Insulin Biosynthesis
Islet tissue from the goosefish (Lophius piscatorius) was incubated in the presence of leucine-H(3). The tissue was then separated into subcellular fractions and the radioactivity determined in total acid alcohol-soluble proteins, insoluble proteins, and insulin. At any time, microsomal protein had a higher activity than secretion granule protein. Pulse-chase experiments further suggest the mic...
متن کاملInsulin secretion: Feed-forward control of insulin biosynthesis?
It has long been accepted wisdom that insulin secreted from islet beta cells has either no effect, or an inhibitory feedback effect, on insulin synthesis and secretion. Recent work suggests, instead, that secreted insulin acts directly on beta cells, via its own receptor, to enhance insulin production in an autocrine feed-forward loop.
متن کاملInsulin receptor biosynthesis in cultured lymphocytes from insulin-resistant patients.
In some patients with genetic forms of extreme insulin resistance, the cause of insulin resistance is a marked (greater than or equal to 90%) reduction in the number of insulin receptors on the cell surface. In the present work, we describe studies of insulin receptor biosynthesis in Epstein-Barr virus (EBV)-transformed lymphocytes from three patients (A-1, A-5, and A-8) with type A extreme ins...
متن کاملBiosynthesis and regulation of the insulin receptor.
The insulin receptor is an integral glycoprotein of the plasma membrane in most mammalian cells. The gene encodes a 190 kDa proreceptor that undergoes a number of processing steps. The gene is constitutively expressed, but at least one form of regulation has been demonstrated. Glucocorticoids increase the number of insulin receptors on the surface of cultured human lymphocytes, a process which ...
متن کاملMetabolic control of insulin gene expression and biosynthesis
The regulation of insulin production by pancreatic p cells is mediated by a number of circulating nutrients and hormones, of which glucose is the predominant physiological stimulus. Over short periods of 1-2 h glucose regulates. insulin biosynthesis mainly at the level of translation (Permutt & Kipnis, 1972). This is in keeping with the requirement to rapidly replenish insulin stores, secreted ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)45633-0